14^th International Conference on Genetics and Genetics Disorder August 03-04, 2020 Zurich, Switzerland

\r\n Fortunately, most children are born healthy with no Medical Problems or birth  defects. However, many children are born with differences in body structure, development of the brain,or body chemistry that can contribute to health, development, school performance, and/or social interaction problems. In order to identify the causes and natural history of these disorders, Pediatric Geneticists are trained. They may suggest tests and treatments that may help you understand and take care of  your child. Pediatric geneticists can also help families understand whether certain Disorders are inherited (from the genes) and provide screening to members of the family who may be at risk of having children with similar problems.

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• \r\n Genetic testing
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• \r\n Genes
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• \r\n Pharmacogenetics
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\r\n Genomics is an interdisciplinary scientific field that focuses on genome structure, work, progress, mapping, and modification. A genome is the entire DNA blueprint of a life system, including most of its characteristics. Like innate characteristics, while insinuating the analysis of individual characteristics and their inheritance components, genomics is concerned with the overall classification and evaluation of characteristics, which organize the age of proteins with the aid of mixes and minister particles.For example, make up body structures, organs and tissues, and also control mixture reactions and movements between cells. Genomics, in the same way, combines genome sequencing and analysis by high-performance DNA sequencing and Bioinformatics businesses to collect and isolate the limit and structure of whole genomes.

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• \r\n High throughput genomic technology
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• \r\n Nutrigenomics
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• \r\n Toxicogenomics
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• \r\n Molecular genetics
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\r\n Cytogenetics is the study of cell structure, area, and ability of chromosomes. It involves studying the number and presence of chromosomes (karyotyping), the physical region of chromosomal properties, and chromosomal actions in procedures such as cell division. The ordinary human cell consists of 46 chromosomes: 22 autosomal pairs, numbered 1-22 by decreasing length query, 1 array of gonosomes, or sex Chromosomes.

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• \r\n Chromosomes
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• \r\n Human mouse somatic cell hybrids
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\r\n The genomes consist of the total amount of genetic material required to encode human life's blueprint. For normal cell division, normal function of our tissues and organs, healthy ageing, and the prevention of diseases such as cancer, successful preservation of Genome Integrity and stability are important. Processes that regulate the preservation of genome integrity include sensing, signalling and repairing DNA damage, chromatin and chromosome DNA damage storage, cell cycle checkpoint regulation, and Cell Death control. Many of the fundamental aspects of the integrity of the genome — such as how cells feel and handle DNA damage — are still not well understood.

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\r\n Cancer is a genetic problem where normal cell enhancement regulation is lost. Now, cancer biology is one of the fastest-growing cell differentiating abilities. At the nuclear level, a mutation(s) of DNA causes cancer, resulting in the development of twisted cells. The increasing dimension of these changes is guarded and occurs in external cells. In any case, the germ line is secured by a couple of individuals. The mutation(s) occurs in two cell characteristics classes on cogenes and the characteristics of the tumour silencer. Tumour silencer characteristics monitor cell division and extension Camouflage under standard conditions. Changes in these characteristics lead to unregulated cell replication which results in tumours with odd cell cycles and growth of tumours. The features of the tumour silencer contribute to the disease by inactivating limit Biogenesi Cancer cytogenetics

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• \r\n Biogenesis
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• \r\n Cancer cytogenetics
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• \r\n Cancer syndromes
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\r\n Neurogenetics studies the role of genetics in nervous system development and function. This recognizes neural features like phenotypes (i.e., observable or non-measurable manifestations of an individual's genetic make-up) and is mainly based on the fact.  Individuals ' nervous systems are belonging to the same species, may not be the same. As the name implies, it draws elements from both Neuroscience and genetics research, concentrating in particular on how its transmitted characteristics influence the genetic code that an organism bears. Mutations can have a wide range of effects on the individual's quality of life in this genetic sequence. In the context of neurogenetics, Neurological Diseases, behaviour and personality are all studied. In the mid to late 1900s, the field of neurogenetics emerged with developments and closely following advances made in the technologies available.

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• \r\n Genetic therapies
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• \r\n Monogenic neurologic diseases
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• \r\n Polygenic diseases
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\r\n Nutrigenetics refers to the application in nutritional research on  genomic .Principle allowing us to formulate associations between specific nutrients and genetic factors, such as how food or food ingredients influence the expression of genes. It aims to identify the genes that influence the risk of diet-related diseases and also help in solving the mechanisms underlying these Genetic Predispositions. Nutrigenetics, on the other hand, shows the alignment of individuals ' genetic makeup with their reactions as well as   specific dietary nutrients. It clarifies various individuals ' responses to the same nutrient. The present study addresses the role of genetic background and diet with their   respect . The   development of chronic conditions such as obesity, cardiovascular disease, hypertension and cancer. These two nutritional branches resemble two sides of a coin, facing opposite sides, but at the same time being intimately attached to each other. Scientific community collaborative efforts are required to strictly follow guidelines on experimental designs, evaluation, and nutritional research data processing. This technique will be helpful in building a reliable database that is useful to Physicians and Dieticians.

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• \r\n Chronic diseases
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• \r\n Gene diet interactions
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\r\n Pharmacy Genetics is the study of how individuals, based on their genetic makeup or chromosomes, react differently to Drug Therapy. Diet, overall health, and  the climate also have a significant influence on the reaction of medication, but none are better measures of how medicine is being handled than the Genes.

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• \r\n Molecular medicine
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• \r\n Pharmacokinetics
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• \r\n Predictive ADME
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\r\n The cardiovascular system, or Circulatory system, delivers oxygen to the heart. It is made up of the heart, arteries, veins; capillaries. CVD is now the world's most frequent cause of death. There are, however, many ways to reduce the risk that these conditions may develop. The treatment, Symptoms, and prevention of conditions that are part of CVD often overlap. We look at the different forms of CVDs in this article, their symptoms and causes, and how to prevent and treat them.

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• \r\n Angina
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• \r\n Arrhythmia
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• \r\n Congential heart disease
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• \r\n Coronary artery disease
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• \r\n Heart attack
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• \r\n Heart failure
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\r\n Genetic Counseling is a mechanism by which individuals and families affected by genetic diseases .They are consulted to help them understand and respond to the health, emotional and family effects of genetic contributors to the disease. Interpretation of family and medical history to determine the probability of disease incidence or recurrence .Training on inheritance, screening, management, prevention, support recommendations to encourage informed choices and risk or Illness Adaptation.

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• \r\n Prenatal diagnosis
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• \r\n Endocrine disorders
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• \r\n Skeletal diseases
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\r\n Human Genetics is that the study of inheritance because it occurs in citizenry. Human genetics encompasses a spread of overlapping fields including: classical genetics, cytogenetics, molecular genetics, biochemical genetics, genomics, population genetics, developmental genetics, Clinical Genetics, and guidance .Human Genetics is the investigation of legacy as it occurs in individuals. Human Genetics joins an arrangement of covering fields including old style hereditary qualities, cytogenetic, sub-atomic hereditary qualities, Biochemical Hereditary qualities, genomics, populace Hereditary qualities, formative hereditary qualities, clinical hereditary qualities, and hereditary advising. Qualities can be the standard factor of the attributes of most human obtained characteristics. Examination of human hereditary qualities can be useful as it can address questions with respect to human conduct, grasp the ailments and headway of effective illness treatment, and appreciate hereditary qualities of human life.

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• \r\n Human Genome mapping
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• \r\n Human Genome sequencing
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• \r\n Human genetic clustering
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• \r\n Human Genetics of Infectious Diseases
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• \r\n Gene Action: Developmental Genetics
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\r\n Personalized medicine hopes to Tailor Therapies to your genetic make-up one day. Modern drugs save millions of lives a year. Even if it works for other people, any medication might not work for you. Or it might cause severe side effects for you but not for someone else. Your Gender, lifestyle and nutrition all have an effect on your drug response. Pharmacogenomics is the study of how the unique genetic structure (genome) of a person influences his or her medication response.

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\r\n Part of the Division of Maternal-Fetal Medicine, the Reproductive Genetics Service was created to help women with medical conditions encountered or made worse by a pregnancy or whose prenatal testing reveals a birth defect or genetic condition in the fetus. Genetics in obstetrics can be complicated because the genetic make-up of three people – the mother, the father of the baby, and the unborn child – must be considered. Many women have a genetic condition that is unrecognized until they become Pregnant. Reproductive Genetics Service geneticists and seven board-certified counselors help couples understand how genetics can affect their pregnancy, offering counseling for those planning to have a baby or women who are already pregnant.

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• \r\n Process of gene therapy
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• \r\n Gene therapy products
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• \r\n Different vectors for gene therapy
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• \r\n Gene therapy for malignant melanoma
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• \r\n Gene therapy for sickle-cell disease
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• \r\n Development of regenerative treatment models
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\r\n Immunogenetics is the branch of medical genetics which investigates the relationship between the immune system and genetics. Autoimmune Disorders, such as diabetes type, are complex genetic traits that are caused by immune system defects. Identifying genes that define immune defects can  identify new target genes for Therapeutic approaches.

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• \r\n Medical genetics
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• \r\n Auto immune diseases
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• \r\n Diabetes
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\r\n Genomics is an interdisciplinary scientific field that focuses on genome structure, work, progress, mapping, and modification. A genome is the entire DNA blueprint of a life system, including most of its characteristics. Like innate characteristics, while insinuating the analysis of individual characteristics and their inheritance components, genomics is concerned with the overall classification and evaluation of characteristics, which organize the age of proteins with the aid of mixes and minister particles.For example, make up body structures, organs and tissues, and also control mixture reactions and movements between cells. Genomics, in the same way, combines genome sequencing and analysis by high-performance DNA sequencing and Bioinformatics businesses to collect and isolate the limit and structure of whole genomes.

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• \r\n High throughput genomic technology
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• \r\n Nutrigenomics
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• \r\n Toxicogenomics
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• \r\n Molecular genetics
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\r\n Biomarkers have rapid evolvement in the advance of personalized medicine and individual health Biomarkers refers to a broad subcategory of medical signs which include objective indications of medical state that are determined from outside the patient – which might be measured accurately and reproducibly. Medical signs change distinction to medical symptoms, that are restricted to those indications of health or sickness perceived by patients themselves.

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\r\n Clinical Trials of Cell and gene therapy product usually variable from the clinical trials design for alternative varieties of pharmaceutical product. This variations in trial design that are necessitated by the distinctive options of those product. The clinical trials additionally replicate previous clinical expertise and proof of drugs. Early experiences with Cell and gene therapy product indicate that some CGT product might cause substantial risks to subjects because of impact at cellular and genetic level. The planning of early-phase Clinical Trials of Cell and gene therapy product usually involves the subsequent thought of clinical questions of safety, diagnosing problems, and chemistry, producing and controls (CMC) problems that can be encountered.

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\r\n Diseases can be treated using viruses as vector to deliver genes in Gene Therapy. Viruses as gene vector, however, can themselves cause problems in that they may initiate inflammation and the genes may be expressed at too high a level or for too long period of exposure. The goal of Nano Technology in gene therapy is delivery of therapeutic genes without a virus, using nanoparticles as non-viral vector to deliver the genes.  The particles can be made with multiple layers so the outer layer with covering of peptide that can target the particles to cells of interest at specific site. The emergent Nanotechnology in gene therapy is used to develop unique approaches in treating the retinopathies and the development of micro and Nano dimensional artificial antigen presenting cells (aAPCs) for cancer immunotherapy. These aAPCs mimic the natural signals in immunity that killer T-cells receive when there is an invader (bacteria, virus, cancer cell, etc.) in the body.

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\r\n A Genetic disorder is a disease caused in whole or in part by a change in the DNA sequence away from the normal sequence. Genetic Disorders can be caused by a mutation in one gene (monogenic disorder), by mutations in multiple genes (multifactorial inheritance disorder), by a combination of gene mutations and environmental factors, or by damage to chromosomes (changes in the number or structure of entire chromosomes, the structures that carry genes).

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\r\n Stem cell treatment is a process where the stem cells are used to make disease free of life through treatment of diseases. They have the potential to treat various life threatening diseases. The unique feature of these cells to divide into multiple stem cells and differentiate into specialized cells makes them apt for the treatment of many diseases. The present researches suggest that stem cells can be used for treating the genetic disorders as well. Apart from treating diseases like brain injuries, Osteoarthritis, diabetes,  learning disabilities, various types of blood cancer, Sickle cell anemia, Parkinson’s, Haemophilia, and Thalassemia, etc.., The cell defect due to mutation result in a wide of variety of genetic disorders. The transplantation of stem cells where the normal stem cell replaces the defected cells can be used for treatment of genetic disorders and diseases.

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\r\n Evolutionary Genetics is that the broad discipline of research that resulted from the blending of genetics and Darwinian evolution, cited because the fashionable synthesis. The force of mutation is the final source of new genetic version inside populations. Although maximum mutations are independent with no effect on fitness or harmful, a few mutations have a small, positive effect on health and these versions are raw substances for gradualist adaptive evolution. Within finite populations, random genetic waft and natural desire affect the mutational version. Natural preference is that the most effective evolutionary force which could produce adaptation, the match between Organism and environment, or preserve genetic states over very long durations of your time within the face of the dispersive forces of mutation and flow

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\r\n Population Genetics is that the study of genetic variation inner populace, and entails the exam and modeling of changes in the frequencies of genes and alleles in population over area and time. A sizeable variety of the genes discovered interior a populace may be polymorphic that is, they may arise in high-quality structures (or alleles). Numerical fashions are implemented to observe and are expecting the prevalence of specific alleles or mixture of alleles in populace, in view of advancements in the molecular information of genetics, Mendel's legal guidelines of inheritance and modern evolutionary theory. The focus is the population or the species not the person. Evolutionary Genetics are the investigation of ways hereditary range activates transformative exchange. It includes subjects, for example, evolution of genome structure, the genetic basis of speciation and adaptation, and genetic alternate in reaction to choice within populations.

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• \r\n Mutation and polymorphism
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• \r\n Admixture and ancestry analysis
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• \r\n Natural selection and adaptation
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• \r\n Hardy-Weinberg equilibrium
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• \r\n Microevolution
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\r\n Developmental Genetics is the study of  how qualities control development and advancement of a living being for a mind-blowing duration cycle. A recently prepared egg cell or Zygote contains a remarkable gathering of qualities that will control its improvement from a solitary cell into a fetus through examples of differential quality articulation during the time spent Embryogenesis.

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• \r\n Zygote
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• \r\n Embryogenesis
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